NIT Warangal

Information

Room No: CY510 +91-870-2462676 rmanda@nitw.ac.in Bio Sketch

Key Notes

Journal(s): 22
PhD: Current - 2

22

PUBLICATIONS

2

DOCTORAL STUDENTS

2

PROJECTS

1

PATENT

Research Areas

Alkyne & Nitrile Chemistry

C-H Functionalization

Metal Catalysis & Medicinal Chemistry

Organic Synthesis

Proteolysis Targeting Chimeras

EDUCATION QUALIFICATION

Degree	Institute	Year
Doctor of Philosophy	CSIR-Indian Institute of Chemical Technology	2021

COURSES HANDLED

Course	L-T-P	Credit	Degree Level
Engineering Chemistry(CY1161)	3-0-2	4	UG
Organometallic Chemistry(CY17003)	3-0-0	3	UG, PG
Organic Chemistry(CYB301)	3-0-2	4	UG
Engineering Chemistry(CY185)	3-0-2	4	UG
Green Chemistry(CY17044)	3-0-0	3	UG, PG
Organic Chemistry Laboratory(CY2204)	0-1-2	2	UG

RESEARCH IDs

PUBLICATIONS

Journal(s)

Application of Hydroxy Propargylic Alcohols in Organic Synthesis, By S Pravinkumar, Attunuri Nagireddy, Hamesh Basumatary, Adita S Madavi, Prathap Reddy Mukthapuram, Rajesh Manda*, Wiley Online Library, The Chemical Record, vol.In Press, pp.e202500266, 2025

Visible-Light-Induced Insertion of Siloxycarbene into Amide N–H Bonds: Synthesis of Carbinolamides from Acylsilanes and Amides, By Praveen Dharavath, Raju Vaggu, Rajesh Manda, René Grée and Saibal Das*, ACS, The Journal of Organic Chemistry, vol.90, pp.1727–1732, 2025

Potent and Selective G Protein-coupled Receptor Kinase 5 Inhibitors: Design, Synthesis, Evaluation, and X-ray Structural Studies, By Arun K Ghosh*, Rajesh Manda, Ranjith Kumar Gadi, Yueyi Chen, Natalie M Galvan, John JG Tesmer, Science Direct , European Journal of Medicinal Chemistry, vol.303, pp.118393, 2025

Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes, By Yueyi Chen, Amol Sonawane, Rajesh Manda, Ranjith Kumar Gadi, John J.G. Tesmer, Arun K. Ghosh*, ELSEVIER, European Journal of Medicinal Chemistry, vol.264, pp.115931, 2024

Recent Progress in Arylmetalative Cyclization/Annulation of Functionalized Alkynes with Organoboranes, By Manda Rajesh* and G. Ranjith Kumar* , Wiley Online Library, Asian Journal of Organic Chemistry, vol.12, pp.e202300106, 2023

Acylsilane Directed Rh-Catalyzed Arene C−H Alkylation with Maleimides and Visible-Light-Induced Siloxycarbene-Amide Cyclization, By Vaggu Raju, Nagender Thadem, Manda Rajesh René Grée and Saibal Das*, ACS, Organic Letters, vol.25, pp.2594, 2023

Synthesis of bridgehead-azacycles via dual C–N/C–C annulation of α-amino acids, aminals and maleimides, By Nagender Thadem, Manda Rajesh, Harikirshna B. and Saibal Das*, RSC, Organic & Biomolecular Chemistry, vol.20, pp.6368, 2022

Activator free diastereoselective 1,3-dipolar cycloaddition: a quick access to coumarin based spiro multi heterocyclic adducts, By Nagender Thadem, Manda Rajesh and Saibal Das*, RSC, RSC Advances, vol.11, pp.29934, 2021

Ni-Catalyzed Electrophile Driven Regioselective Arylative Cyclization of Ortho-Functional Diaryl Acetylenes for Pyridine and Indene Derivatives., By S. Maneesh Kumar Reddy, A. Nagireddy, Manda Rajesh, V. Ganesh and Maddi Sridhar Reddy*. , RSC, Organic Chemistry Frontiers, vol.7, pp.30, 2020

A Sequential Activation of Alkyne & C-H Bonds for the tandem Cyclization & Annulation of Alkynols and Maleimides through Cooperative Sc (III) and Cp* Free Co (II) Catalysis, By G. Ravi Kumar, Manda Rajesh (equal first authorship), S. M. K. Reddy, B. Sridhar and Maddi Sridhar Reddy*, ACS, Organic Letters, vol.22, pp.5326, 2020

Lewis Acid Catalyzed Decarboxylative Annulation of 2-Aminoindole-3-Carboxylate with Ynals Involving [3+2] Spirocycloaddition and 2,3-Aza Migration, By Manda Rajesh, Ravi Kumar, Surendra Puri, N. Jagadish Babu and Maddi Sridhar Reddy*, ACS, Organic Letters, vol.22, pp.1117, 2020

Propargylic Alcohols as Coupling Partners in Transition‐Metal‐Catalyzed Arene C‐H Activation, By G. Ranjith Kumar, Manda Rajesh, Shuimu Lin and Shouping Liu*, Wiley Online Library, Advanced Synthesis & Catalysis, vol.362, pp.5238, 2020

Mycobacterial Protein tyrosine kinase A phosphorylates PtpA at Tyrosineresidues and the mechanism is stalled by the novel series of inhibitors, By Swati Jaiswal, Aditi Chatterjee, Sapna Pandey, Kiran Lata, G. Ranjith Kumar, Manda Rajesh, Sanjay Kumar, Maddi Sridhar Reddy, Ravishankar Ramachandran and Kishore K Srivastava.*, Taylor & Francis, Journal of Drug Targeting, vol.27, pp.51, 2019

Rh(III)-Catalyzed Intramolecular Oxidative Annulation of Propargyl Amino Phenyl Benzamides to Access Pyrido/Isoquinolino Quinoxalinone, By G. Ravi Kumar, Ravi Kumar, Manda Rajesh, B. Sridhar and Maddi Sridhar Reddy*, Wiley Online Library, Advanced Synthesis & Catalysis, vol.361, pp.4825, 2019

Base Mediated Tandem Vinylogous Addition and Cyclization of γ–Phosphonyl/Sulfonyl Crotonates and Ynones: Synthesis of Functionalized 2-Pyrones., By Matam Parameshwar, Manda Rajesh, B. Sridhar and Maddi Sridhar Reddy*, ACS, ACS Omega, vol.4, pp.18846, 2019

Nickel Catalyzed syn-Selective Aryl Nickelation and Cyclization of Aldehyde/Enone-Tethered Terminal Alkynes with Arylboronic Acids, By Manda Rajesh, S. Maneesh Kumar Reddy, Surendra Puri, B. Sridhar and Maddi Sridhar Reddy*. , ACS, The Journal of Organic Chemistry, vol.83, pp.15361, 2018

3-Heterosubstituted Benzofurans from Hydroxyphenyl Propargyl Alcohols via ortho-Quinone Methide through A Metal/Catalyst free Conjugate addition/Oxy-Cyclization., By Manda Rajesh, S. Maneesh, G. Ranjith Kumar and Maddi Sridhar Reddy*, ACS, ACS Omega, vol.3, pp.17155, 2018

A nickel-catalyzed anti-carbometallative cyclization of alkyne–azides with organoboronic acids: synthesis of 2,3-diarylquinolines. , By G. Ranjith Kumar, Ravi Kumar, Manda Rajesh and Maddi Sridhar Reddy*, RSC, Chemical Communications, vol.54, pp.759, 2018

Ag-Catalyzed Intramolecular Sequential Vicinal Diamination of Alkynes with Isocyanates: Synthesis of Fused Indole-Cyclic Urea Derivatives, By Manda Rajesh, Surendra Puri, Ruchir Kant and Maddi Sridhar Reddy*, ACS, The Journal of Organic Chemistry, vol.82, pp.5169, 2017

A stereoselective thiocyanate conjugate addition to electron deficient alkynes and concomitant cyclization to N,S-heterocycles, By Vikas Dwivedi, Manda Rajesh (equal first authorship), Ravi Kumar, Ruchir Kant and Maddi Sridhar Reddy*, RSC, Chemical Communications, vol.53, pp.11060, 2017

Synthesis of Substituted Furan/Pyrrole-3-carboxamides through a Tandem Nucleopalladation and Isocyanate Insertion , By Manda Rajesh, Surendra Puri, Ruchir Kant and Maddi Sridhar Reddy*. , ACS, Organic Letters, vol.18, pp.4332, 2016

Pd-Catalyzed Isocyanide Assisted Reductive Cyclization of 1 (2- Hydroxyphenyl)-propargyl Alcohols for 2 Alkyl/Benzyl Benzofurans and Their Useful Oxidative Derivatization, By Manda Rajesh, Nuligonda Thirupathi, Thota Jagadeshwar Reddy, Sanjeev Kanojiya, and Maddi Sridhar Reddy*, ACS, The Journal of Organic Chemistry, vol.80, pp.12311, 2015

Patent(s)

Selective g protein-coupled receptor kinase 5 inhibitors, compositions, and methods of use (WO2023168246A2)

PROJECT / CONSULTANCY

Oxidative Cyclization Strategies for the Synthesis of Novel Heterocycles and Their Biological Evaluation

Role: Co-Principal Investigator
Type: Research
Sponsor: RVR Labs
Project Cost (INR): 2255000
Date of Commencement: 14-06-2025
Duration: 36 Months
Status: Ongoing

Arylative Cyclization of Functionalized Alkynes for Indolizne and Pyrido-indole Derivatives: Their Application in Cancer Research as Proteolysis Targeting Chimeras

Role: Principal Investigator
Type: Research
Sponsor: NITW
Project Cost (INR): 500000
Date of Commencement: 07-05-2025
Duration: 12 Months
Status: Ongoing

RESEARCH FELLOWS / PhD STUDENTS

Current PhD Students

Dhiddi Mahendra Varma

Area of Research: Harnessing enynes:

Pravinkumar S

Area of Research: Exploring the π-Substrates Reactivity through Transition Metal Catalysis for Complex Molecular Diversity

CONFERENCE / WORKSHOP / SYMPOSIUM / SHORT TERM COURSE / FACULTY DEVELOPMENT PROGRAMME

AWARDS AND ACCOLADES

2021

NOST-SAILIFE Best Thesis Award-2021, India

2018

Sri Gopalkishanrao Vepachedu Memorial Award

CSIR-CDRI Incentive Award 2018

2016

CSIR-CDRI Incentive Award 2016

ADDITIONAL RESPONSIBILITIES

Last updated on January 15, 2026

Prof. Rajesh Manda

Assistant Professor Gr-II

Department of Chemistry

Information

Key Notes

22

2

2

1

Research Areas

Current PhD Students