NIT Warangal

Information

Room No: 408, Department of Biotechnology +91-870-2464208 thyagesh@nitw.ac.in https://sites.google.com/nitw.ac.in/thyagesh-lab-nitw/home Bio Sketch

Key Notes

Journal(s): 16
Book Chapter(s): 1
PhD: Current - 3 Awarded - 1

17

PUBLICATIONS

4

DOCTORAL STUDENTS

4

PROJECTS

1

PATENT

Research Areas

Biomechanics

Cancer Biology

Computational Drug discovery and dynamics

Molecular Biophysics

Molecular Dynamics of Macromolecules

Structural dynamics of ribosomes

Structural Proteomics (X-ray Crystallography and Cryo-EM)

EDUCATION QUALIFICATION

Degree	Institute	Year
Doctor of Philosophy	Indian Institute of Science (IISc Bangalore)	2017
Master of Technology	West Bengal University of Technology Kolkata	2007
Bachelor of Technology	PSG College of Technology, Coimbatore/Anna university, Chennai	2005

COURSES HANDLED

Course	L-T-P	Credit	Degree Level
Biology for Engineers(BT1161)	2-0-0	2	UG
Computational Methods in Drug Discovery(BT403)	3-0-2	4	UG
Bioengineering(BT231)	2-0-0	2	UG
Principles of Biosafety, Bioethics & Intellectual Property Rights(BT464)	3-0-0	3	UG
Structural Biology(BT305)	3-0-0	3	UG
Drug and Vaccine Informatics(BT5166)	3-0-0	3	PG
Entrepreneurship, IPR, Biosafety & Bioethics(BT5172)	3-0-0	3	PG

RESEARCH IDs

PUBLICATIONS

Journal(s)

Histone deacetylase 6 (HDAC 6) inhibition by mangrove-derived fat and fatty acids , By Ediriweera, M. K., Sandamalika, W. M. G., Gopi, J., Manokaran, S., Viswanathan Joydas, T., Sethi, D., & Chandran, T. , Taylor & Francis, Natural Product Research, vol., pp.1-10, 2026

In silico structural and mechanistic sights into the N-glycosidase mechanism of Shiga toxin, By PK Madasu, T Chandran, Springer Nature, Archives of Toxicology, vol.99, pp.1143-1152, 2025

Identification of potential therapeutic targets of fatty acids for inflammatory bowel diseases: An in silico approach, By PV Thillany, MK Ediriweera, PK Madasu, T Chandran, CSIR–NIScPR, Indian Journal of Biochemistry and Biophysics (IJBB), vol.62, pp.754-765, 2025

In silico structural characterization and mechanistic insights of the alpha kinase (EIF2AK3) mediated translation regulation, By Madasu, P. K and Chandran, T, Springer, J. Mol. Model., vol., pp., 2024

In silico identification and characterisation of pathogenic genetic variants (nsSNPs) in the eukaryotic initiation factors eIF2 and eIF2B affecting miRNA binding sites, By PK Madasu, V Lokesh Subrahmanyam, T Chandran, Springer Nature, Egy. Journal of Medical Human Genetics, vol.25, pp.124, 2024

Structural Insights into the Toxicity of type II Ribosome Inactivating Proteins (RIPs): A Molecular Dynamics Study, By Madasu, P. K and Chandran, T , Taylor & Francis , J. Biomol. Str. & Dyn, vol.Accepted, pp., 2024

Insights into the microevolution of SARS-ACE2 interactions: in silico analysis of glycosylation and SNP pattern, By Madasu, P. K, Maity. A, Ghosh, S. K, and Chandran, T, Taylor & Francis , J. Biomol. Str. & Dyn, vol.41(13), pp.6442-6449, 2023

In-silico structural studies on anti-inflammatory activity of phytocompounds from the genus Andrographis, By Kizhakedathil, M.P.J., Madasu, P. K., Deepa S. V and Chandran, T , Taylor & Francis , J. Biomol. Str. & Dyn, vol., pp.0739-1102, 2023

Betacoronaviral lectins: Identification through a genomic search—A structural and evolutionary biology perspective, By Madasu, P. K, Maity. A, Patra D, and Chandran, T , Taylor & Francis , Journal of Carbohydrate Chemistry, vol.42, pp.112-134, 2023

Selection of start codon during mRNA scanning in eukaryotic translation initiation, By Basu, I., Chandran, T., Gorai, G., Maiti, P.K., and Hussain., T , Nature portfolio, Comm. Biol, vol.5(1), pp.587, 2022

Ligand binding and retention in snake gourd seed lectin (SGSL). A crystallographic, thermodynamic and molecular dynamics study, By Chandran, T., Sivaji, N., Surolia, A and Vijayan, M, Oxford University Press, Glycobiology, vol.28(12), pp.968-977, 2018

Ligand binding and retention in snake gourd seed lectin (SGSL). A crystallographic, thermodynamic and molecular dynamics study, By T Chandran, N Sivaji, A Surolia, M Vijayan, Oxford University Press, Glycobiology, vol.28, pp.968–977, 2018

Structural studies on a non-toxic homologue of type II RIPs from bitter gourd: Molecular basis of non-toxicity, conformational selection and glycan structure, By T Chandran, A Sharma, M Vijayan, Springer Nature, Journal of Biosciences, vol.40, pp.929-941, 2015

The sequence and structure of snake gourd (Trichosanthes anguina) seed lectin, a three-chain nontoxic homologue of type II RIPs, By Alok Sharma, G Pohlentz, KB Bobbili, AA Jeyaprakash, T Chandran, et al., International Union of Crystallography (IUCr), Acta Crystallographica Section D: Biological Crystallography, vol.69 (8), pp.1493–1503, 2013

Crystallization and preliminary X-ray studies of a galactose-specific lectin from the seeds of bitter gourd (Momordica charantia), By T Chandran, A Sharma, M Vijayan, International Union of Crystallography, Acta Crystallographica Section F: Structural Biology and Crystallization Communications, vol.66, pp.1037-1040, 2010

A novel Plasmodium falciparum erythrocyte binding protein associated with the merozoite surface, PfDBLMSP, By T Wickramarachchi, AL Cabrera, D Sinha, S Dhawan, T Chandran, et al., Elsevier, International Journal for Parasitology, vol.39 (7), pp.763–773, 2009

Book Chapter(s)

Generation of ligand specificity and modes of oligomerization in β-prism I fold lectins By T Chandran, A Sharma, M Vijayan in Advances in Protein Chemistry and Structural Biology, Elsevier, International Book Series, 2013

Patent(s)

NapNGo – Foldable Multipurpose Car Bed Design. (482828-001)

PROJECT / CONSULTANCY

Structural and Mechanistic Insights into Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4)-Mediated Ferroptosis: Implications for Diabetic Complications.

Role: Principal Investigator
Type: Research
Sponsor: Anusandhan National Research Foundation, Govt. of India
Project Cost (INR): 6500000
Date of Commencement: 09-03-2026
Duration: 36 Months
Status: Ongoing

Sustainable Bioproduction of Nitrilase using Unicellular Cyanobacterial Species: In Vivo and In Silico Enzyme Characterization

Role: Co-Principal Investigator
Type: Research
Sponsor: Department of Biotechnology (DBT), Government of India
Project Cost (INR): 4840000
Date of Commencement: 01-10-2025
Duration: 24 Months
Status: Ongoing

Mathematical modelling and simulation of blood flow in sickle cell disease

Role: Principal Investigator
Type: Research
Sponsor: SERB, DST, Govt. of India.
Project Cost (INR): 660000
Date of Commencement: 13-03-2024
Duration: 36 Months
Status: Ongoing

Computational structure-based drug design: Identifying antivirals from natural products targeting SARS-CoV-2

Role: Principal Investigator
Type: Research
Sponsor: Extreme Science and Engineering Discovery Environment (XSEDE
Project Cost (INR): 5000000
Date of Commencement: 24-03-2021 Date of Completion: 24-03-2024
Duration: 36 Months
Status: Completed

RESEARCH FELLOWS / PhD STUDENTS

Current PhD Students

Devaki Sethi

Area of Research: Structural biology of Fatty Acid Binding Proteins (FABs)

Neha Gupta

Area of Research: Computational Modelling and Structural biology of Macromolecules

Umasree Gudipati

Area of Research: Structural Bioinformatics

Previous PhD Students

Madasu Pavan Kumar (2025)

Area of Research: Structural biology of eukaryotic initiation factors

CONFERENCE / WORKSHOP / SYMPOSIUM / SHORT TERM COURSE / FACULTY DEVELOPMENT PROGRAMME

AWARDS AND ACCOLADES

2025

Editorial Board–BMC Mol & Cell Biol, Springer

Editorial Board- Scientific Reports, Nature

Review Editor-Front. Mol. Biosci.

Review Editor Front. Cell Dev. Biol.

ADDITIONAL RESPONSIBILITIES

Founding faculty sponsorer Biophysics Society (US) students chapter (Continuing from January, 2025)
Member NITW-Media team (Continuing from June, 2024)
PhD Coordinator, Department of Biotechnology (March, 2024 - June, 2025)
Member of NITW-Media Team (November, 2023 - December, 2025)
Tinkering Laboratory coordinator from Dept. of Biotech. (Continuing from July, 2023)
Institute Ranking committee member (June, 2023 - September, 2024)
Departmental MoU In charge (Continuing from May, 2023)
Faculty Coordinator, SPIC MACAY -NITW Chapter (March, 2023 - March, 2025)
iGeM Faculty advisor (January, 2022 - February, 2024)
Faculty Coordinator, Photography club-NITW (March, 2021 - March, 2023)
Member of NIT-Warangal Learning Management System Technical Committee (June, 2020 - July, 2022)
Member of NIT Warangal Teaching Learning and Resources Working Group (TLRWG) (June, 2020 - November, 2024)

Last updated on March 23, 2026

Prof. Thyageshwar Chandran

Assistant Professor Gr-I

Department of Biotechnology

Information

Key Notes

17

4

4

1

Research Areas

Current PhD Students

Previous PhD Students